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Evaluation is of crucial importance and should meet professional standards in its design. In practice, organizational peculiarities and available resources characterize the search for the "right" approach. When used as a quality development tool, internal or self-evaluation should primarily be useful. It should generate information to answer organizational questions and provide results as a basis for discussion in decision-making processes.
Software development is a complex task. Merely focussing on functional requirements is not sufficient any more. Developers are responsible to take many non-functional requirements carefully into account. Security is amongst the most challenging, as getting it wrong will result in a large user-base being potentially at risk. A similar situation exists for administrators. Security defaults have been put into place here to encounter lacking security controls. As first attempts to establish security by default in software development are flourishing, the question on their usability for developers arises.
In this paper we study the effectiveness and efficiency of Content Security Policy (CSP) enforced as security default in a web framework. When deployed correctly, CSP is a valid protection mean in a defence-in-depth strategy against code injection attacks. In this paper we present a first qualitative laboratory study with 30 participants to discover how developers deal with CSP when deployed as security default. Our results emphasize that the deployment as security default has its benefits but requires careful consideration of a comprehensive information flow in order to improve and not weaken security. We provide first insights to inform research about aiding developers in the creation of secure web applications with usable security by default.
Dementia not only affects the cognitive capabilities, especially memory and orientation, but also physical capabilities, which are associated with a decrease of physical activities. Here, ICT can play a major role to improve health, quality of life and wellbeing in older adults suffering from dementia and related stakeholders, such as relatives, professional and informal caregivers. The aim of the presented system is to increase physical and cognitive capabilities of people with dementia and their caregivers to support them in daily life activities, reduce the strain of the caregivers and improve both their wellbeing.
Once aberrantly activated, the Wnt/βcatenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against βcatenin, as it serves a role on the cytoplasm and the nucleus. In addition, speciallygenerated lymphocytes are recruited for the purpose of treating liver cancer. Peripheral blood mononuclear lymphocytes are expanded by the timely addition of interferon γ, interleukin (IL)1β, IL2 and anticluster of differentiation 3 antibody. The resulting cells are called cytokineinduced killer (CIK) cells. The present study utilised these cells and combine them with drugs inhibiting the Wnt pathway in order to examine whether this resulted in an improvement in the killing ability of CIK cells against liver cancer cells. Drugs including ethacrynic acid (EA) and ciclopirox olamine (CPX) were determined to be suitable candidates, as determined by previous studies. Drugs were administered on their own and combined with CIK cells and then a cell viability assay was performed. These results suggest that EAtreated cells demonstrated apoptosis and were significantly affected compared with untreated cells. Unlike EA, CPX killed normal and cancerous cells even at low concentrations. Subsequent to combining EA with CIK cells, the potency of killing was increased and a greater number of cells died, which proves a synergistic action. In summary, EA may be used as an antihepatocellular carcinoma drug, while CPX possesses a high toxicity to cancerous as well as to normal cells. It was proposed that EA should be integrated into present therapeutic methods for cancer.
Scientific or statistical research has long been the domain of dedicated programming languages such as R, SPSS or SAS. A few years other competitors entered the arena, among them Python with its powerful SciPy package. The following article introduces SciPy by applying a small subset of its functionality to a well-known dataset.
Polyurethane (PU) coatings were successfully produced using unmodified kraft lignin (KL) as an environmentally benign component in contents of up to 80 wt%. Lignin samples were precipitated from industrial black liquor in aqueous solution working at room temperature and different pH levels (pH 2 to pH 5). Lignins were characterized by UV-Vis, FTIR, pyrolysis-GC/MS, SEC and 31P-NMR. Results show a correlation between pH level, OH number and molecular weight Mw of isolated lignins. Lignin-based polyurethane coatings were prepared in an efficient one step synthesis dissolving lignin in THF and PEG425 in an ultrasonic bath followed by addition of 4,4-diphenylmethanediisocyanate (MDI) and triethylamine (TEA). Crosslinking was achieved under very mild conditions (1 hour at room temperature followed by 3 hours at 35 °C). The resulting coatings were characterized regarding their physical properties including ATR-IR, TGA, optical contact angle, light microscopy, REM-EDX and AFM data. Transparent homogeneous films of high flexibility resulted from lignins isolated at pH 4, possessing a temperature resistance up to 160 °C. Swelling tests revealed a resistance against water. Swelling in DMSO depends on index, pH of precipitation and catalyst utilization for PU preparation. According to AFM studies, surface roughness is between 10 and 28 nm.
Multidisciplinary, multicultural, and multitasking has taken center stage in the global educational debate. Globalization and improvement in communication have affected the way organisations operate and hence influenced whom they hire. Today, it is common practice to work with people from diverse backgrounds and it requires competencies that go beyond general project management. Intercultural awareness, networking in different global communities, and learning to develop specific communication strategies for different stakeholders is all part of the package of skills and competencies that are required in today's interconnected world. This has indirect implication on the nature of skills and competencies institutions/universities must equip their students with to enable them to compete successfully in the working world.
The formulation of transport network problems is represented as a translation between two domain specific languages: from a network description language, used by network simulation community, to a problem description language, understood by generic non-linear solvers. A universal algorithm for this translation is developed, an estimation of its computational complexity given, and an efficient application of the algorithm demonstrated on a number of realistic examples. Typically, for a large gas transport network with about 10K elements the translation and solution of non-linear system together require less than 1 sec on the common hardware. The translation procedure incorporates several preprocessing filters, in particular, topological cleaning filters, which accelerate the solution procedure by factor 8.
Innovations in the mobility industry such as automated and connected cars could significantly reduce congestion and emissions by allowing the traffic to flow more freely and reducing the number of vehicles according to some researchers. However, the effectiveness of these sustainable product and service innovations is often limited by unexpected changes in consumption: some researchers thus hypothesize that the higher comfort and improved quality of time in driverless cars could lead to an increase in demand for driving with autonomous vehicles. So far, there is a lack of empirical evidence supporting either one or other of these hypotheses. To analyze the influence of autonomous driving on mobility behavior and to uncover user preferences, which serve as indicators for future travel mode choices, we conducted an online survey with a paired comparison of current and future travel modes with 302 participants in Germany. The results do not confirm the hypothesis that ownership will become an outdated model in the future. Instead they suggest that private cars, whether conventional or fully automated, will remain the preferred travel mode. At the same time, carsharing will benefit from full automation more than private cars. However, the findings indicate that the growth of carsharing will mainly be at the expense of public transport, showing that more emphasis should be placed in making public transport more attractive if sustainable mobility is to be developed.
Transition point prediction in a multicomponent lattice Boltzmann model: Forcing scheme dependencies
(2018)
Large, high-resolution displays are highly suitable for creation of digital environments for co-located collaborative task solving. Yet, placing multiple users in a shared environment may increase the risk of interferences, thus causing mental discomfort and decreasing efficiency of the team. To mitigate interferences coordination strategies and techniques were introduced. However, in a mixed-focus collaboration scenarios users switch now and again between loosely and tightly collaboration, therefore different coordination techniques might be required depending on the current collaboration state of team members. For that, systems have to be able to recognize collaboration states as well as transitions between them to ensure a proper adjustment of the coordination strategy. Previous studies on group behavior during collaboration in front of large displays investigated solely collaborative coupling states, not transitions between them though. To address this gap, we conducted a study with 12 participant dyads in front of a tiled display and let them solve two tasks in two different conditions (focus and overview). We looked into group dynamics and categorized transitions by means of changes in proximity, verbal communication, visual attention, visual interface, and gestures. The findings can be valuable for user interface design and development of group behavior models.
Towards explaining deep learning networks to distinguish facial expressions of pain and emotions
(2018)
Deep learning networks are successfully used for object and face recognition in images and videos. In order to be able to apply such networks in practice, for example in hospitals as a pain recognition tool, the current procedures are only suitable to a limited extent. The advantage of deep learning methods is that they can learn complex non-linear relationships between raw data and target classes without limiting themselves to a set of hand-crafted features provided by humans. However, the disadvantage is that due to the complexity of these networks, it is not possible to interpret the knowledge that is stored inside the network. It is a black-box learning procedure. Explainable Artificial Intelligence (AI) approaches mitigate this problem by extracting explanations for decisions and representing them in a human-interpretable form. The aim of this paper is to investigate the explainable AI method Layer-wise Relevance Propagation (LRP) and apply it to explain how a deep learning network distinguishes facial expressions of pain from facial expressions of emotions such as happiness and disgust.
Digitisation has brought a major upheaval to the mobility sector, and in the future, self-driving cars will probably be one of the transport modes. This study extends transport and user acceptance research by analysing in greater depth how the new modes of autonomous private cars, autonomous carsharing and autonomous taxis fit into the existing traffic mix from today's perspective. It focuses on accounting for relative added value. For this purpose, user preference theory was used as a base for an online survey (n=172) on the relative added value of the new autonomous traffic modes. Results show that users see advantages in the autonomous modes for driving comfort and time utilization whereas, in comparison to conventional cars, in many other areas – especially in terms of driving pleasure and control – they see no advantages or even relative disadvantages. Compared to public transport, the autonomous modes offer added values in almost all characteristics. This analysis at the partwor th level provides a more detailed explanation for user acceptance of automated driving.
We present the performance of the upGREAT heterodyne array receivers on the SOFIA telescope after several years of operations. This instrument is a multi-pixel high resolution (R≳107) spectrometer for the Stratospheric Observatory for Far-Infrared Astronomy (SOFIA). The receivers use 7-pixel subarrays configured in a hexagonal layout around a central pixel. The low frequency array receiver (LFA) has 2×7 pixels (dual polarization), and presently covers the 1.83–2.07THz frequency range, which allows to observe the [CII] and [OI] lines at 158μm and 145μm wavelengths. The high frequency array (HFA) covers the [OI] line at 63μm and is equipped with one polarization at the moment (7 pixels, which can be upgraded in the near future with a second polarization array). The 4.7THz array has successfully flown using two separate quantum-cascade laser local oscillators from two different groups. NASA completed the development, integration and testing of a dual-channel closed-cycle cryocooler system, with two independently operable He compressors, aboard SOFIA in early 2017 and since then, both arrays can be operated in parallel using a frequency separating dichroic mirror. This configuration is now the prime GREAT configuration and has been added to SOFIA’s instrument suite since observing cycle 6.
In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new approaches are urgently required. A cell-stress response pathway, the unfolded protein response (UPR), has emerged as a promising target for the development of novel breast cancer treatments. This pathway is activated in response to a disturbance in endoplasmic reticulum (ER) homeostasis but has diverse physiological and disease-specific functions. In breast cancer, UPR signalling promotes a malignant phenotype and can confer tumours with resistance to widely used therapies. Here, we review several roles for UPR signalling in breast cancer, highlighting UPR-mediated therapy resistance and the potential for targeting the UPR alone or in combination with existing therapies.
Through the “Act to Strengthen the Non-financial Reporting by Corporations in their Management and Group Management Reports” (Gesetz zur Stärkung der nichtfinanziellen Berichterstattung der Unternehmen in ihren Lage- und Konzernlageberichten) (CSR Directive Transposition Act, „CSR-RUG“) of 11 April 2017[1], the German Bundestag implemented Directive 2014/95/EU (“CSR Directive”)[2] into German law. Following the European impetus, the CSR-RUG enriches the traditional repertoire of forms of action under environmental law by a further instrument. Already the regulatory context gives an idea of its atypical nature: The centrepiece of the CSR-RUG is the amendment of and addition to the Third Book of the German Commercial Code (Handelsgesetzbuch, “HGB”), which deals with the “trading books” of undertakings, i.e., accounting and reporting requirements. Since the reporting year 2017, large capital market-oriented corporations must report extensively within the framework of their annual management reports on their activities and effects in certain areas of “Corporate Social Responsibility”. This also includes environmental matters. The transparency and publicity this entails is intended to generate positive stimuli for more responsible, sustained and not least of all environmentally friendly entrepreneurial action.
Following a brief presentation of the European legal bases and their implementation in Germany (I.), we will classify the provisions within the underlying concept of Corporate Social Responsibility (II.) and analyse and systemise the governance effects of non-financial reporting (III.). A few remarks on selected aspects of the chosen approach and its implementation (IV.) as well as an outlook summarising our conclusions (V.) will complete this article. By detailing the German approach to transposing the CSR Directive, this paper intends to provide an example of the challenges member state legislators face when complying with modern governance concepts such as Corporate Social Responsibility by way of non-financial reporting obligations.
[1] Federal Law Gazette, Part I 2017, 802 et seq.
[2] Directive 2014/95/EU of the European Parliament and of the Council 22 October 2014 amending Directive 2013/34/EU as regards disclosure of non-financial and diversity information by certain large undertakings and groups, OJ EU No. L 330, p. 1.
Maintaining orientation in an environment with non-Earth gravity (1 g) is critical for an astronaut's operational performance. Such environments present a number of complexities for balance and motion. For example, when an astronaut tilts due to ascending or descending an inclined plane on the moon, the gravity vector will be tilted correctly, but the magnitude will be different from on earth. If this results in a mis-perceived tilt, then that may lead to postural and perceptual errors, such as mis-perceiving the orientation of oneself or the ground plane and corresponding errors in task judgment.
The paper contributes to the debate on the political economy of implementation of propoor social policy. It argues for a broadening of the debate, which is dominated by technocratic arguments, emphasizing the lack of financial resources, technology or skills as the major barriers for effective implementation. Describing the dynamic interplay of ‘formal’ operational programme structures and ‘informal’ traditional institutions in delivering the CT-OVC – the largest and oldest cash transfer programme in Kenya – it argues for the need to look more closely into the local political economy as an important mediating arena for implementing social policies. Implementation is heavily contingent upon the local social, political and institutional context that influences and shapes its outcomes. These processes are highly dynamic and ambivalent evolving between ‘formal’ and ‘informal’ structures and institutions. They may change over time and place, challenging the implicit assumption that programmes are evenly implemented across geographic and political entities.
This policy brief investigates the costs of child poverty in the Balkans, including deprivation in terms of education, health, and social mobility. It then lays out the potential of social protection, most notably in terms of building resilence and fostering development. Set against recent case studies from around the world, including Cambodia and Uganda, the brief gives policy recommendations on various critical issues including transfer schemes, transformative measures, and (alternative) care for children with disabilities.
This policy brief is part of a wider research project entitled ‘Building the Economic Case for Investments in Social Protection’. The research aims at demonstrating the potential impacts of social protection on inclusive growth. The project is a collaborative effort between the Maastricht Graduate School of Governance at the University of Maastricht and United Nations University-MERIT, NL; the Global Development Institute at the University of Manchester, UK; the School of Social Science at the University of Makerere, Uganda; and the Expanding Social Protection Programme of the Ugandan Ministry of Gender, Labour and Social Development. This project is part of the research agenda of the Knowledge Platform Inclusive Development Policies and funded by the Ministry of Foreign Affairs of the Netherlands through the NWO-WOTRO programme.
We present a novel forearm-and-glove tactile interface that can enhance 3D interaction by guiding hand motor planning and coordination. In particular, we aim to improve hand motion and pose actions related to selection and manipulation tasks. Through our user studies, we illustrate how tactile patterns can guide the user, by triggering hand pose and motion changes, for example to grasp (select) and manipulate (move) an object. We discuss the potential and limitations of the interface, and outline future work.
This book is about how computer systems might be designed to serve their users rather better. It deals with how to study the natural behaviour of users to see how computer systems might best help them, and how one might also involve them in the design of computer systems that will assist them in their everyday practices.
This paper analyzes the complex effects and risks of social protection programmes in Ghana and Kenya on poor people’s human wellbeing, voice and empowerment and interactions with the social protection regulatory framework and policy instruments. For this purpose, it adopts a comprehensive Inclusive Development framework to systematically explore the complex effects of cash transfers and health insurance at the individual, household and community level. The findings highlight the positive provisionary and preventive effects of social protection, but also illustrate that the poorest are still excluded and that promotive effects, in the form of enhanced productivity, manifest themselves mainly for the people who are less resource poor. They can build more effectively upon an existing asset base, capabilities, power and social relations to counter the exclusionary mechanisms of the system, address inequity concerns and offset the transaction costs of accessing and benefitting from social protection. The inclusive development framework enables to lay these complex effects and interactions bear, and points to areas that require more longitudinal and mixed methodology research.
Social Insurance
(2018)
Extending coverage through contributory social insurance or other contributory programs is tempting for governments as a potential avenue for mobilizing new resources and creating new fiscal space. Such extension has clear limits, however: it applies only to those in the labor market who have employment status with high degree of formality and whose incomes are significantly above subsistence level and received regularly. It also requires administrative structures with capacity to regularly register incomes of those covered, and to collect contributions.
This chapter analyzes the potential of social insurance (also called contributory social protection) in the 16 Asian countries reviewed in this publication to fill the protection and coverage gaps in income security. It focuses on pensions, but also reviews other benefits temporarily replacing lost labor income due to events such as sickness, maternity, and unemployment. As current labor market structures largely determine the chances of extending coverage through these means, this chapter also examines their characteristics and analyzes coverage by the different forms of social insurance and assesses the potential for extension.
Social Assistance
(2018)
If the first Sustainable Development Goal (SDG) to “End poverty in all its forms everywhere” is to be taken seriously, most low- and middle-income countries face a huge challenge. An estimated 1 billion people have indeed escaped extreme poverty since the early 1990s, and the global poverty rate fell from 35% in 1990 to 10.7% in 2013, but the absolute number of people living below the international poverty line of $1.90 at purchasing power parity has hardly changed. Countries in Asia contributed greatly to the overall decline in poverty rates: from 2012 to 2013, over 100 million people in Asia left extreme poverty behind, notably in India, Indonesia, and the People’s Republic of China (PRC) (World Bank 2016). Yet the living standards of those still below that line have hardly improved (Ravallion 2016). The achievement of the first SDG requires additional efforts at global and national levels, particularly on policies that address chronic poverty traps and that improve the outcomes of poor and vulnerable populations.
Smallholder farmers as a backbone for the implementation of the Sustainable Development Goals
(2018)
Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells
(2018)
The need for bone grafts is high, due to age-related diseases, such as tumor resections, but also accidents, risky sports, and military conflicts. The gold standard for bone grafting is the use of autografts from the iliac crest, but the limited amount of accessible material demands new sources of bone replacement. The use of mesenchymal stem cells or their descendant cells, namely osteoblast, the bone-building cells and endothelial cells for angiogenesis, combined with artificial scaffolds, is a new approach. Mesenchymal stem cells (MSCs) can be obtained from the patient themselves, or from donors, as they barely cause an immune response in the recipient. However, MSCs never fully differentiate in vitro which might lead to unwanted effects in vivo. Interestingly, purinergic receptors can positively influence the differentiation of both osteoblasts and endothelial cells, using specific artificial ligands. An overview is given on purinergic receptor signaling in the most-needed cell types involved in bone metabolism-namely osteoblasts, osteoclasts, and endothelial cells. Furthermore, different types of scaffolds and their production methods will be elucidated. Finally, recent patents on scaffold materials, as wells as purinergic receptor-influencing molecules which might impact bone grafting, are discussed.
The elucidation of conformations and relative potential energies (rPEs) of small molecules has a long history across a diverse range of fields. Periodically, it is helpful to revisit what conformations have been investigated and to provide a consistent theoretical framework for which clear comparisons can be made. In this paper, we compute the minima, first- and second-order saddle points, and torsion-coupled surfaces for methanol, ethanol, propan-2-ol, and propanol using consistent high-level MP2 and CCSD(T) methods. While for certain molecules more rigorous methods were employed, the CCSD(T)/aug-cc-pVTZ//MP2/aug-cc-pV5Z theory level was used throughout to provide relative energies of all minima and first-order saddle points. The rPE surfaces were uniformly computed at the CCSD(T)/aug-cc-pVTZ//MP2/aug-cc-pVTZ level. To the best of our knowledge, this represents the most extensive study for alcohols of this kind, revealing some new aspects. Especially for propanol, we report several new conformations that were previously not investigated. Moreover, two metrics are included in our analysis that quantify how the selected surfaces are similar to one another and hence improve our understanding of the relationship between these alcohols.
Companies investing in the occupied Palestinian territories are faced with a dilemma. Undoubtedly, the creation of jobs helps to put young Palestinians to work. Experience shows that especially young males are less likely to radicalise and commit crimes when having an occupation. However, negative press coverage due to the disputed status of the territory can force companies to withdraw. CSR activities can help to demonstrate that a company has a genuine interest in its employees and community at large. Our article looks into one particular case of an Israeli company that had to withdraw their operation due to public pressure, mainly Western media. We give recommendations how such failure could have been avoided by using the right kind of CSR activities that address the needs of the Palestinians.
Shared Autonomous Vehicles: Potentials for a Sustainable Mobility and Risks of Unintended Effects
(2018)
Automated and connected cars could significantly reduce congestion and emissions through a more efficient flow of traffic and a reduction in the number of vehicles. An increase in demand for driving with autonomous vehicles is also conceivable due to higher comfort and improved quality of time using driverless cars. So far, empirical evidence supporting this hypothesis is missing. To analyze the influence of autonomous driving on mobility behavior and to uncover user preferences, which serve as an indicator for future travel mode choices, we conducted an online survey with a paired comparison of current and future travel modes with 302 German participants. The results do not confirm the hypothesis that ownership will become an outdated model in the future. Instead they suggest that private cars, whether traditional or fully automated, will remain the preferred travel mode. At the same time, carsharing will benefit from full automation more than private cars. However, findings indicate that the growth of carsharing will mainly be at the expense of public transport, showing that more effort should be placed in making public transportation more attractive if sustainable mobility is to be developed.
Social protection measures require sustainable financing – creating and maintaining adequate fiscal space at the national level. Good governance of social protection at all stages – planning policies, policy reforms, and implementation – requires continuous monitoring of its performance and finances, including long-term projections and simulations of cost and benefits of different social protection programs and overall social protection systems. These projections and simulations should take into account demographic trends, including demographic ageing.
This paper documents the reversal of pension privatization and the reforms that took place in the 1990s and 2000s in Poland. The report analyses the political economy of different reform proposals, and the characteristics of the new pension system, including laws enacted, coverage, benefit adequacy, financing and contribution rates, governance and social security administration, social dialogue, positive impacts and other key issues of Poland’s pension system.
The design of an efficient digital circuit in term of low-power has become a very challenging issue. For this reason, low-power digital circuit design is a topic addressed in electrical and computer engineering curricula, but it also requires practical experiments in a laboratory. This PhD research investigates a novel approach, the low-power design laboratory system by developing a new technical and pedagogical system. The low-power design laboratory system is composed of two types of laboratories: the on-site (hands-on) laboratory and the remote laboratory. It has been developed at the Bonn-Rhine-Sieg University of Applied Sciences to teach low-power techniques in the laboratory. Additionally, this thesis contributes a suggestion on how the learning objectives can be complemented by developing a remote system in order to improve the teaching process of the low-power digital circuit design. This laboratory system enables online experiments that can be performed using physical instruments and obtaining real data via the internet. The laboratory experiments use a Field Programmable Gate Array (FPGA) as a design platform for circuit implementation by students and use image processing as an application for teaching low-power techniques.
This thesis presents the instructions for the low-power design experiments which use a top-down hierarchical design methodology. The engineering student designs his/her algorithm with a high level of abstraction and the experimental results are obtained and measured at a low level (hardware) so that more information is available to correctly estimate the power dissipation such as specification, latency, thermal effect, and technology used. Power dissipation of the digital system is influenced by specification, design, technology used, as well as operating temperature. Digital circuit designers can observe the most influential factors in power dissipation during the laboratory exercises in the on-site system and then use the remote system to supplement investigating the other factors. Furthermore, the remote system has obvious benefits such as developing learning outcomes, facilitating new teaching methods, reducing costs and maintenance, cost-saving by reducing the numbers of instructors, saving instructor time and simplifying their tasks, facilitating equipment sharing, improving reliability, and finally providing flexibility of usage the laboratories.
This policy brief is part of a wider research project entitled ‘Building the Economic Case for Investments in Social Protection’. The research aims at demonstrating the potential impacts of social protection on inclusive growth. The project is a collaborative effort between the Maastricht Graduate School of Governance at the University of Maastricht and United Nations University-MERIT, NL; the Global Development Institute at the University of Manchester, UK; the School of Social Science at the University of Makerere, Uganda; and the Expanding Social Protection Programme of the Ugandan Ministry of Gender, Labour and Social Development. This project is part of the research agenda of the Knowledge Platform Inclusive Development Policies and funded by the Ministry of Foreign Affairs of the Netherlands through the NWO-WOTRO programme.
Influence of design of extrusion blow molding (EBM) in terms of extrusion direction set-up and draw ratio as well as process conditions (mold temperature) on storage modulus of high density polyethylene EBM containers was analyzed with dynamic mechanical analysis. All three parameters - mold temperature, flow direction and draw ratio - are statistically significant and lead to relative and absolute evaluation of storage modulus. Furthermore, flow induced changes in crystallinity was analyzed by differential scanning calorimetry. Obtained data on deformation properties can be employed for more sophisticated finite element simulations with the aim to reach more sustainable extrusion blow molding production.
Quantifying the spectrum occupancy in an outdoor 5 GHz WiFi network with directional antennas
(2018)
WiFi-based Long Distance networks are seen as a promising alternative for bringing broadband connectivity to rural areas. A key factor for the profitability of these networks is using license free bands. This work quantifies the current spectrum occupancy in our testbed, which covers rural and urban areas alike. The data mining is conducted on the same WiFi card and in parallel with an operational network. The presented evaluations reveal tendencies for various aspects: occupancy compared to population density, occupancy fluctuations, (joint)-vacant channels, the mean channel vacant duration, different approaches to model/forecast occupancy, and correlations among related interfaces.
Pyrolysis–Gas Chromatography
(2018)
The methodology of analytical pyrolysis-GC/MS has been known for several years, but is seldom used in research laboratories and process control in the chemical industry. This is due to the relative difficulty of interpreting the identified pyrolysis products as well as the variety of them. This book contains full identification of several classes of polymers/copolymers and biopolymers that can be very helpful to the user. In addition, the practical applications can encourage analytical chemists and engineers to use the techniques explored in this volume.
The structure and the functions of various types of pyrolyzers and the results of the pyrolysis–gas chromatographic–mass spectrometric identification of synthetic polymers/copolymers and biopolymers at 700°C are described. Practical applications of these techniques are also included, detailing the analysis of microplastics, failure analysis in the automotive industry and solutions for technological problems.
Text is one of the key sources of information for social sciences and humanities which, with the rise and development of computational technologies, has been mostly available via digital libraries, archives and websites. It enables researchers to increasingly deal with large scale text corpora that require the use of advanced software tools to process them and extract information. Computational linguistics - a discipline that has emerged on the border of computer science, linguistics and statistics - has achieved certain results in automated text analysis and information extraction, e.g., tools for part-of-speech tagging, grammar parsing, semantic role labelling, sentiment analysis and anaphora resolution have been developed and successfully used in many scientific projects. However, there still exists a gap between technology available and the needs of social sciences: named entity recognizers are incapable of identifying actors, sentiment analysis just provides the overall mood of an expression but is not able to identify the evaluation of information by the utterer, topic modeling tools can only assign a topic to a document, but fall short of measuring its frame.
Project Overview
(2018)
The project "German-African University Partnership Platform for the Development of Entrepreneurs and Small/Medium Enterprises" started in 2015 within the framework of the program "University-Business-Partnerships between Higher Education Institutions and Business Partners in Germany and in Developing Countries", funded by the German Ministry of Economic Cooperation and Development (BMZ), and the German Academic Exchange Service (DAAD). It is carried out by Hochschule Bonn-Rhein-Sieg, University of Applied Sciences in Germany (H-BRS), the University of Cape Coast (UCC) in Ghana, and the University of Nairobi (UoN) in Kenya.
Argentina substantially contributes to the global organic agriculture and food sector due to its large areas of organically managed agricultural land. However, most of the organic production is intended for export. Overall, food supply for the domestic organic market is hardly tapped. Based on this, we investigate the current importance of organic agriculture and food production as well as consumption attitudes and behavior within the country. The novelty of the study also lies in the observation, documentation and analysis of latest stakeholder‐driven developments towards organic agriculture and food. Furthermore, the publication allows the Argentinean organic market to be significantly more visible for the international audience.
Persons with disabilities have much lower employment rates than the population as a whole and are at a significantly higher risk of living in poverty (OECD, 2011, pp. 50-56 and WHO, 2011, pp. 237-239). However, many of the barriers people with disabilities face, with regards to labor market reintegration, are in fact avoidable. There has for quite some time been evidence that differences in employment and wages, between disabled and non-disabled workers, can only to a limited extent be explained by differences in human capital endowments and productivity (Kidd, Sloane, & Ferko, 2000). Instead, factors such as the absence of access to education and training, and the lack of financial assistance provided are actually significant drivers of labor market exclusion (OECD, 2009, p.15; WHO, 2011, p.239).
Robot deployment in realistic environments is challenging despite the fact that robots can be quite skilled at a large number of isolated tasks. One reason for this is that robots are rarely equipped with powerful introspection capabilities, which means that they cannot always deal with failures in an acceptable manner; in addition, manual diagnosis is often a tedious task that requires technicians to have a considerable set of robotics skills. In this paper, we discuss our ongoing efforts to address some of these problems. In particular, we (i) present our early efforts at developing a robotic black box and consider some factors that complicate its design, (ii) explain our component and system monitoring concept, and (iii) describe the necessity for remote monitoring and experimentation as well as our initial attempts at performing those. Our preliminary work opens a range of promising directions for making robots more usable and reliable in practice.
Poland
(2018)
Poland belongs to the first wave of pension reformers in Central and Eastern Europe. The Polish pension reform of the late 1990s can serve as a case study for the challenges faced when implementing a radical paradigmatic pension reform towards a privatized DC scheme. This report analyses the background of the original reform, discusses its political, social and economic impact and explains the reasons for later reform reversals. The report stresses that the two re-reform waves, which took place in 2011 and 2013, were mainly driven by fiscal considerations. Since the current system maintains the DC scheme applied to both public and private tiers, the recent reversal of privatization will not improve benefit levels.
More and more low-power wide-area networks (LPWANs) are being deployed and planning the gateway locations plays a significant role for the network range, performance and profitability. We choose LoRa as one LPWAN technology and evaluated the accuracy of the Received Signal Strength Indication (RSSI) of different chipsets in a laboratory environment. The results show the chipsets report significantly different RSSI. To estimate the range of a LPWAN beforehand, path loss models have been proposed. Compared to previous work, we evaluated the Longley-Rice Irregular Terrain Model which makes use of real-world elevation data to predict the path loss. To verify the results of that prediction, an extensive measurements campaign in a semi-urban area in Germany has been conducted. The results show that terrain data can increase the prediction accuracy.
The Life Cycle Assessment (LCA) approach is the most important tool in the evaluation of environmental (sustainability) impacts of products and processes. We used the method to conduct an impact analysis with regard to raw material inputs (pulp) for the German paper production industry. In our analysis, we compare the environmental effects of primary sulphate pulp, scrap paper pulp and grass-based pulp and estimate their impacts in the impact categories "greenhouse gas emissions", "eutrophication" as well as "energy and water consumption". Furthermore, we discuss the opportunities of the methodical approach and some general problems and limits of the application of a LCA. In conclusion, we found environmental advantages for the use of grass as an alternative resource in the German paper production industry, especially in the fields of transport and water consumption.
The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual disability in all human societies. Caused by the transcriptional silencing of a single gene, the fragile x mental retardation gene FMR1, FXS is characterized by a variety of symptoms, which range from mental disabilities to autism and epilepsy. More than 20 years ago, a first animal model was described, the Fmr1 knock-out mouse. Several other models have been developed since then, including conditional knock-out mice, knock-out rats, a zebrafish and a drosophila model. Using these model systems, various targets for potential pharmaceutical treatments have been identified and many treatments have been shown to be efficient in preclinical studies. However, all attempts to turn these findings into a therapy for patients have failed thus far. In this review, I will discuss underlying difficulties and address potential alternatives for our future research.
Entering the work envelope of an industrial robot can lead to severe injury from collisions with moving parts of the system. Conventional safety mechanisms therefore mostly restrict access to the robot using physical barriers such as walls and fences or non-contact protective devices including light curtains and laser scanners. As none of these mechanisms applies to human-robot-collaboration (HRC), a concept in which human and machine complement one another by working hand in hand, there is a rising need for safe and reliable detection of human body parts amidst background clutter. For this application camera-based systems are typically well suited. Still, safety concerns remain, owing to possible detection failures caused by environmental occlusion, extraneous light or other adverse imaging conditions. While ultrasonic proximity sensing can provide physical diversity to the system, it does not yet allow to reliably distinguish relevant objects from background objects.This work investigates a new approach to detecting relevant objects and human body parts based on acoustic holography. The approach is experimentally validated using a low-cost application-specific ultrasonic sensor system created from micro-electromechanical systems (MEMS). The presented results show that this system far outperforms conventional proximity sensors in terms of lateral imaging resolution and thus allows for more intelligent muting processes without compromising the safety of people working close to the robot. Based upon this work, a next step could be the development of a multimodal sensor systems to safeguard workers who collaborate with robots using the described ultrasonic sensor system.
New approaches in securing more sustainable urban food futures: case from Cologne-Bonn region
(2018)
Further development on globally convergent algorithms for solution of stationary network problems is presented. The algorithms make use of global non-degeneracy of Jacobi matrix of the system, composed of Kirchhoff's flow conservation conditions and transport element equations. This property is achieved under certain monotonicity conditions on element equations and guarantees an existence of a unique solution of the problem as well as convergence to this solution from an arbitrary starting point. In application to gas transport networks, these algorithms are supported by a proper modeling of gas compressors, based on individually calibrated physical characteristics. This paper extends the modeling of compressors by hierarchical methods of topological reduction, combining the working diagrams for parallel and sequential connections of compressors. Estimations are also made for application of topological reduction methods beyond the compressor stations in generic network problems. Efficiency of the methods is tested by numerical experiments on realistic networks.
As a result of ageing societies, the prevalence of dementia, and accordingly the need of care is increasing rapidly. Here, the use of ICT-based technologies may facilitate and promote a self-sustaining life-style for people with dementia and their caregivers. The presented poster describes early findings from the project MobiAssist and outlines the ICT-based training system. The system aims to increase the physical and cognitive capabilities of people with dementia, relief the caregivers and improve wellbeing of involved parties.
3-Hydroxy-3-methylglutaryl-coenzyme A lyase (HMGCL, HMGCL) deficiency is a rare inborn error of ketogenesis. Even if the ketogenic enzyme is fully disrupted, an elevated signal for the ketone body acetoacetic acid is a frequent observation in the analysis of urinary organic acids, at least if derivatization is performed by methylation. We provide an explanation for this phenomenon and trace it back to degradation of the derivatized 3-hydroxy-3-methylglutaric acid and high temperature of the injector of the gas chromatograph.
The use of wearable devices or “wearables” in the physical activity domain has been increasing in the last years. These devices are used as training tools providing the user with detailed information about individual physiological responses and feedback to the physical training process. Advantages in sensor technology, miniaturization, energy consumption and processing power increased the usability of these wearables. Furthermore, available sensor technologies must be reliable, valid, and usable. Considering the variety of the existing sensors not all of them are suitable to be integrated in wearables. The application and development of wearables has to consider the characteristics of the physical training process to improve the effectiveness and efficiency as training tools. During physical training, it is essential to elicit individual optimal strain to evoke the desired adjustments to training. One important goal is to neither overstrain nor under challenge the user. Many wearables use heart rate as indicator for this individual strain. However, due to a variety of internal and external influencing factors, heart rate kinetics are highly variable making it difficult to control the stress eliciting individually optimal strain. For optimal training control it is essential to model and predict individual responses and adapt the external stress if necessary. Basis for this modeling is the valid and reliable recording of these individual responses. Depending on the heart rate kinetics and the obtained physiological data, different models and techniques are available that can be used for strain or training control. Aim of this review is to give an overview of measurement, prediction, and control of individual heart rate responses. Therefore, available sensor technologies measuring the individual heart rate responses are analyzed and approaches to model and predict these individual responses discussed. Additionally, the feasibility for wearables is analyzed.
This case study is based on Azuri Health Ltd, a small company in Kenya that specializes mainly in the manufacture of dried fruit and flours. The company was started in 2010 and currently has 15 employees. It buys fruits, especially mangoes from farmers, processes them and markets them in- and outside of Kenya as dried fruits. This value addition enhances the shelf life of the products which would otherwise spoil within a few days after ripening.
Due to regionalization and global competition, many companies have turned their attention to other markets outside the domestic ones in anticipation of securing profitable market(s) for their products. Cormart (Nigeria) Limited is one of such companies, seeking to expand beyond its domestic borders. Cormart is a Nigerian trading company specializing in Industrial Raw Materials and Chemicals. It represents the business interests of top Multinational Companies that wish to do business in Nigeria. In line with its expansion strategy, Cormart seeks to introduce its newly developed spray starch product (RENEW) into the Ghanaian market.
Preleukemic clones carrying BCR-ABLp190 oncogenic lesions are found in neonatal cord blood, where the majority of preleukemic carriers do not convert into precursor B-cell acute lymphoblastic leukemia (pB-ALL). However, the critical question of how these preleukemic cells transform into pB-ALL remains undefined. Here we model a BCR-ABLp190 preleukemic state and show that limiting BCR-ABLp190 expression to hematopoietic stem/progenitor cells (HS/PC) in mice (Sca1-BCR-ABLp190) causes pB-ALL at low penetrance, which resembles the human disease. pB-ALL blast cells were BCR-ABL-negative and transcriptionally similar to pro-B/pre-B cells, suggesting disease onset upon reduced Pax5 functionality. Consistent with this, double Sca1-BCR-ABLp190+Pax5+/- mice developed pB-ALL with shorter latencies, 90% incidence, and accumulation of genomic alterations in the remaining wild-type Pax5 allele. Mechanistically, the Pax5-deficient leukemic pro-B cells exhibited a metabolic switch towards increased glucose utilization and energy metabolism. Transcriptome analysis revealed that metabolic genes (IDH1, G6PC3, GAPDH, PGK1, MYC, ENO1, ACO1) were upregulated in Pax5-deficient leukemic cells, and a similar metabolic signature could be observed in human leukemia. Our studies unveil the first in vivo evidence that the combination between Sca1-BCR-ABLp190 and metabolic reprogramming imposed by reduced Pax5 expression is sufficient for pB-ALL development. These findings might help to prevent conversion of BCR-ABLp190 preleukemic cells.
Antioxidant activity is an essential aspect of oxygen-sensitive merchandise and goods, such as food and corresponding packaging, cosmetics, and biomedicine. Technical lignin has not yet been applied as a natural antioxidant, mainly due to the complex heterogeneous structure and polydispersity of lignin. This report presents antioxidant capacity studies completed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The influence of purification on lignin structure and activity was investigated. The purification procedure showed that double-fold selective extraction is the most efficient (confirmed by ultraviolet-visible (UV/Vis), Fourier transform infrared (FTIR), heteronuclear single quantum coherence (HSQC) and 31P nuclear magnetic resonance spectroscopy, size exclusion chromatography, and X-ray diffraction), resulting in fractions of very narrow polydispersity (3.2⁻1.6), up to four distinct absorption bands in UV/Vis spectroscopy. Due to differential scanning calorimetry measurements, the glass transition temperature increased from 123 to 185 °C for the purest fraction. Antioxidant capacity is discussed regarding the biomass source, pulping process, and degree of purification. Lignin obtained from industrial black liquor are compared with beech wood samples: antioxidant activity (DPPH inhibition) of kraft lignin fractions were 62⁻68%, whereas beech and spruce/pine-mixed lignin showed values of 42% and 64%, respectively. Total phenol content (TPC) of the isolated kraft lignin fractions varied between 26 and 35%, whereas beech and spruce/pine lignin were 33% and 34%, respectively. Storage decreased the TPC values but increased the DPPH inhibition.
Antioxidant activity is an essential feature required for oxygen-sensitive merchandise and goods, such as food and corresponding packaging as well as materials used in cosmetics and biomedicine. For example, vanillin, one of the most prominent antioxidants, is fabricated from lignin, the second most abundant natural polymer in the world. Antioxidant potential is primarily related to the termination of oxidation propagation reactions through hydrogen transfer. The application of technical lignin as a natural antioxidant has not yet been implemented in the industrial sector, mainly due to the complex heterogeneous structure and polydispersity of lignin. Thus, current research focuses on various isolation and purification strategies to improve the compatibility of lignin material with substrates and enhancing its stabilizing effect.
Renewable resources gain increasing interest as source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorization for biomedical utilization is rapidly growing. Depending on resource and isolation procedure, lignin shows specific antioxidant and antimicrobial activity. Today, efforts in research and industry are directed toward lignin utilization as renewable macromolecular building block for the preparation of polymeric drug encapsulation and scaffold materials. Within the last five years, remarkable progress has been made in isolation, functionalization and modification of lignin and lignin-derived compounds. However, literature so far mainly focuses lignin-derived fuels, lubricants and resins. The purpose of this review is to summarize the current state of the art and to highlight the most important results in the field of lignin-based materials for potential use in biomedicine (reported in 2014–2018). Special focus is drawn on lignin-derived nanomaterials for drug encapsulation and release as well as lignin hybrid materials used as scaffolds for guided bone regeneration in stem cell-based therapies.
Renewable resources are gaining increasing interest as a source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorization for biomedical utilization is rapidly growing. Depending on its resource and isolation procedure, lignin shows specific antioxidant and antimicrobial activity. Today, efforts in research and industry are directed toward lignin utilization as a renewable macromolecular building block for the preparation of polymeric drug encapsulation and scaffold materials. Within the last five years, remarkable progress has been made in isolation, functionalization and modification of lignin and lignin-derived compounds. However, the literature so far mainly focuses lignin-derived fuels, lubricants and resins. The purpose of this review is to summarize the current state of the art and to highlight the most important results in the field of lignin-based materials for potential use in biomedicine (reported in 2014⁻2018). Special focus is placed on lignin-derived nanomaterials for drug encapsulation and release as well as lignin hybrid materials used as scaffolds for guided bone regeneration in stem cell-based therapies.
The curricula of all degree programs at H-BRS have many different practice-oriented activities and focus on hands-on learning. In labs and small classrooms (30–60 persons), students get a personalized learning environment which is complemented with many individual and group projects that foster collaborative work situations. There are several main areas that students learn from working with industry, local organizations or public institutions.
Gas chromatography (GC) is a type of chromatography. According to the International Union of Pure and Applied Chemistry (IUPAC) recommendation, gas chromatography is defined as a separation technique in which the mobile phase is a gas. Gas chromatography is always carried out in a column [1]. GC is a separation and detection method for sample mixtures, whose components can be volatilized without thermal decomposition.
According to the International Union of Pure and Applied Chemistry (IUPAC) recommendation, analytical pyrolysis (Py) is defined as the characterization in an inert atmosphere of a material or a chemical process by a chemical degradation reaction(s) induced by thermal energy [1]. Thermal degradation under controlled conditions is often used as a part of an analytical procedure, either to render a sample into a suitable form for subsequent analysis by gas chromatography (GC), mass spectrometry (MS), gas chromatography coupled with the mass spectrometry (GC/MS), with the Fourier-transform infrared spectroscopy (GC/FTIR), or by direct monitoring as an analytical technique in its own right [2].