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A method for minimum range extension with improved accuracy in triangulation laser range finder
(2011)
Nitric oxide (NO) is an important regulator of Na+ reabsorption by pulmonary epithelial cells and therefore of alveolar fluid clearance. The mechanisms by which NO affects epithelial ion transport are poorly understood and vary from model to model. In this study, the effects of NO on sodium reabsorption by H441 cell monolayers were studied in an Ussing chamber. Two NO donors, (Z)-1-[N-(3-aminopropyl)-N-(n-propyl) amino]diazen-1-ium-1,2-diolate and diethylammonium(Z)-1-(N, N-diethylamino) diazen-1-ium-1,2-diolate, rapidly, reversibly, and dose-dependently reduced amiloride-sensitive, short-circuit currents across H441 cell monolayers. This effect was neutralized by the NO scavenger hemoglobin and was not observed with inactive NO donors. The effects of NO were not blocked by 8-bromoguanosine-3',5'-cyclic monophosphate or by soluble guanylate cyclase inhibitors (methylene blue and 1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one) and were therefore independent of soluble guanylate cyclase signaling. NO targeted apical, highly selective, amiloride-sensitive Na+ channels in basolaterally permeabilized H441 cell monolayers. NO had no effect on the activity of the human epithelial sodium channel heterologously expressed in Xenopus oocytes. NO decreased Na+/K+-ATPase activity in apically permeabilized H441 cell monolayers. The inhibition of Na+/K+-ATPase activity by NO was reversed by mercury and was mimicked by N-ethylmaleimide, which are agents that reverse and mimic, respectively, the reaction of NO with thiol groups. Consistent with these data, S-NO groups were detected on the Na+/K+-ATPase a subunit in response to NO-donor application, using a biotin-switch approach coupled to a Western blot. These data demonstrate that, in the H441 cell model, NO impairs Na+ reabsorption by interfering with the activity of highly selective Na+ channels and the Na+/K+-ATPase.
The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance. An important mechanism regulating alveolar fluid clearance is sodium transport across the alveolar epithelium. Transepithelial sodium transport is largely dependent on the activity of sodium channels in alveolar epithelial cells. This paper describes how sodium channels contribute to alveolar fluid clearance under physiological conditions and how deregulation of sodium channel activity might contribute to the pathogenesis of lung diseases associated with pulmonary edema. Furthermore, sodium channels as putative molecular targets for the treatment of pulmonary edema are discussed.
The Web has become an indispensable prerequisite of everyday live and the Web browser is the most used application on a variety of distinct devices. The content delivered by the Web has changed drastically from static pages to media-rich and interactive Web applications offering nearly the same functionality as native applications, a trend which is further pushed by the Cloud and more specifically the Cloud’s SaaS layer. In the light of this development, security and performance of Web browsing has become a crucial issue.
Routing Attacks are a serious threat to communication in tactical MANETs. TOGBAD is a centralised approach, using topology graphs to detect such attacks. In this paper, we present TOGBAD's newly added wormhole detection capability. It is an adaptation of a wormhole detection method developed by Hu et al. This method is based on nodes' positions. We adapted it to the specific properties of tactical environments. Furthermore, we present simulation results which show TOGBAD's performance regarding the detection of wormhole attacks.
The usage of link quality based routing metrics significantly improves the quality of the chosen paths and by that the performance of the network. But, attackers may try to exploit link qualities for their purposes. Especially in tactical multi-hop networks, routing may fall prey to an attacker. Such routing attacks are a serious threat to communication. TOGBAD is a centralised approach, using topology graphs to detect routing attacks. In this paper, we enhance TOGBAD with the capability to detect fake link qualities. We use a Challenge/Response method to estimate the link qualities in the network. Based on this, we perform plausibility checks for the link qualities propagated by the nodes in the network. Furthermore, we study the impact of attackers propagating fake link qualities and present simulation results showing TOGBAD's detection rate.
NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site
(2011)
Software offshoring has been established as an important business strategy over the last decade. While research on such forms of Global Software Development (GSD) has mainly focused on the situation of large enterprises, small enterprises are increasingly engaging in offshoring, too. Representing the biggest share of the German software industry, small companies are known to be important innovators and market pioneers. They often regard their flexibility and customer-orientation as core competitive advantages. Unlike large corporations, their small size allows them to adopt software development approaches that are characterized by a high agility and flat hierarchies. At the same time, their distinct strategies make it unlikely that they can simply adopt management strategies that were developed for larger companies.
Flexible development approaches like the ones preferred by small corporations have proven to be problematic in the context of offshoring, as their strong dependency on constant communication is strongly affected by the various barriers of international cooperation between companies. Cooperating closely over companies’ borders in different time zones and in culturally diverse teams poses complex obstacles for flexible management approaches. It is still a matter of discussion in fields like Software Engineering and Computer Supported Cooperative Work how these obstacles can be tackled and how they affect companies in the long term. Hence, it is agreed that we need a more detailed understanding of distributed software development practices in order to come to feasible technological and organizational solutions.
This dissertation presents results from two ethnographically-informed case studies of software offshoring in small German enterprises. By adopting Anselm Strauss’ concept of articulation work, we want to deepen the understanding of managing distributed software development in flexible, customer-oriented organizations. In doing so, we show how practices of coordinating inter-organizational software development are closely related to aspects of organizational learning in small enterprises. By means of interviews with developers and project managers from both parties of the cooperation, we do not only take into account the multiple perspectives of the cooperation, but also include the socio-cultural background of international software development projects into our analysis.
The recent explosion of available audio-visual media is the new challenge for information retrieval research. Audio speech recognition systems translate spoken content to the text domain. There is a need for searching and indexing this data which possesses no logical structure. One possible way to structure it on a high level of abstraction is by finding topic boundaries. Two unsupervised topic segmentation methods were evaluated with real-world data in the course of this work. The first one, TSF, models topic shifts as fluctuations in the similarity function of the transcript. The second one, LCSeg, approaches topic changes as places with the least overlapping lexical chains. Only LCSeg performed close to a similar real-world corpus. Other reported results could not be outperformed. Topic analysis based on the repeated word usage models renders topic changes more ambiguous than expected. This issue has more impact on the segmentation quality than the state-of-the-art ASR word error rate. It could be concluded that it is advisable to develop topic segmentation algorithms with real-world data to avoid potential biases to artificial data. Unlike evaluated approaches based on word usage analysis, methods operating with local contexts can be expected to perform better through emulation of semantic dependencies.
This study presents the findings of a quantitative study on the use of Open Educational Resources (OER) and Open Educational Practices (OEP) in Higher Education and Adult Learning Institutions. The study is based on the results of an online survey targeted at four educational roles: educational policy makers; institutional policy makers/managers; educational professionals; and learners. The report encompasses five chapters and four annexes. Chapter I presents the survey and Chapter II discloses the main research questions and models. Chapter III characterises the universe of respondents. Chapter IV advances with a detailed survey analysis including an overview of key statistical data. Finally, Chapter V provides an exploratory in-depth analysis of some key issues: representations, attitudes and uses of OEP. The table of contents and the complete list of diagrams and tables can be found at the end of the report.
In an explorative study, we investigated on German schoolteachers how they use, reuse, produce and manage Open Educational Resources. The main questions in this research have been, what their motivators and barriers are in their use of Open Educational Resources, what others can learn from their Open Educational Practices, and what we can do to raise the dissemination level of OER in schools.
This paper addresses special skills, learners in Internet-based learning scenarios need. In self-directed learning scenarios, as most Internet-based learning scenarios are designed, learners bear the responsibility for their learning progress. To ease this task, institutions could prime the learners for the situation which may be quite different to their previous learning experiences. Basing on a Delphi-study, conducted with experts from the e-Learning sector in Germany, Austria, and Switzerland, the basic requirements have been determined.
Adaptability as a Special Demand on Open Educational Resources: The Cultural Context of e-Learning
(2011)
Producing and providing Open Educational Resources (OERs) is driven by the concepts of openness and sharing. Although there already are a lot of free high-quality resources available, practitioners often rather rewrite learning resources than creatively embed (and thus, reuse) existing OERs. In this paper, we analyse the reasons for this in two different educational contexts. As a result of this analysis, we found that the uncertainty on possible adaptation needs is one of the major barriers. In order to overcome this barrier and make different learning contexts comparable, we analysed the context of learners and in particular, in the research project ‘Learning Culture’, we investigated the field of culturally motivated expectations and attitudes of learners. This paper shows the results of this research project and discusses which cultural issues should be taken into consideration when OERs are to be adapted from one to another cultural context.
The roadmap for quality and innovation through open educational practices has been conceived as a number of steps, a conceptual document, which can be used by organisations, leaners or professionals in order to improve their open educational practices. After the development of the core concept of the OPAL project, the guidelines for OEP, it became clear that these guidelines, would have to play an important part on the roadmap exercise, because they represent the very essence of how to foster and stimulate open educational practices. The roadmap therefore is meant to be an instrument, a tool which helps the different stakeholders to use the guidelines for their own context and purpose.